Production of chitosan complexes with 3ʹ,5ʹ-сyclic diadenosine monophosphate

To solve the problem of delivering pharmacologically promising 3ʹ,5ʹ-cyclic diadenosine monophosphate (cyclo-diAMP) to target cells in humans and animals, complexes above-mentioned dinucleotide with natural polymer – chitosan were originally synthesized by ionotropic gelation technique. It was found that binding degree cyclo-diAMP this biopolymeric carrier reaches 60 %; wherein capacity obtained respect is 800–860 µg/mg produced complex. Cyclo-diAMP has also been shown elute from complex citrate-phosphate buffer (pH 7.4) up 36 % 21 hours. The results testify favor potential application cyclodiAMP for prolonged delivery studied cyclic cells.